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Pathogenesis of acute respiratory distress syndrome

As inflammasomes induce pyroptosis and inflammation with potentially catastrophic results, they are tightly regulated through a two-step process of priming and activation ( 2.1.1 Priming of NLRP3 Resting cells typically exhibit low levels of NLRP3 mRNA, necessitating a priming step to enhance its expression (Franchi et al., 2009)